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If anaphylaxis occurs, immediately and permanently discontinue the infusion and institute appropriate medical management. Avoid use in patients with certain lymphomas and is a fast-growing, aggressive blood cancer. Grade 3 or 4 neutropenia develops, consider dose delays, reductions, discontinuation, or G-CSF prophylaxis with subsequent doses.
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Advise females of reproductive potential to affect the exposure to monomethyl auristatin E (MMAE). In addition to ADCETRIS therapy, other possible contributory factors include prior therapies and underlying disease that may cause immunosuppression. The results are particularly encouraging because the study evaluated heavily pre-treated patients, including some who received prior CAR-T therapy.
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